PROMISING DIRECTIONS FOR THE APPLICATION OF PIPERIDINE DERIVATIVES AS STRUCTURAL COMPONENTS OF NEUROTROPIC DRUGS

Piperidine is one of the most common heterocycles, and its derivatives are found in many pharmacological groups, including neurotropic drugs. These compounds numerous among analgesics, and, addition to “classical” promedol, fentanyl derivatives, paper presents results studying new with analgesic activity piperidine cycle. Reviews such antipsychotics as haloperidol risperidone have been considered, showing antipsychotic through their effects on dopamine serotonin receptors elucidated. The data influence methylphenidate brain case attention deficit/ hyperactivity disorder (ADHD) analyzed, which help understand disturbances occurring this disease. Tiagabine has considered an antiepileptic agent reducing number seizures resistant forms partial epilepsy, well activation microglia may be effective neurodegenerative diseases. last section devoted drugs for treatment Alzheimer’s disease (AD), namely donepezil, modifications, some potentially capable inhibiting AD progression inhibition Aβ42 protein synthesis.